Details

Autor(en) / Beteiligte

• Chen, Yufeng
• Yang, Ruitong
• Xiao, Fuhong
• Xu, Tianci
• Mao, Guojiang
• Deng, Guo-Jun

Titel

Copper-Catalyzed Synthesis of 3‑Aryl‑9H‑imidazo[1,5‑a]indol-9-ones Using Oxygen as the Sole Oxidant

Ist Teil von

• Organic letters, 2023-05, Vol.25 (20), p.3702-3707

Ort / Verlag

American Chemical Society

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A three-component strategy was developed for 3-phenyl-9H-imidazo­[1,5-a]­indol-9-one preparation from indole-2-carboxaldehydes, aromatic aldehydes, and ammonium acetate under copper catalysis conditions. In this process, a new five-membered ring was formed and the C3 position in the indole substrate was selectively oxidized into a ketone skeleton using oxygen as the sole oxidant and ammonium acetate as the nitrogen source. Furthermore, same products also could be achieved from indole-2-carboxaldehydes and benzyl amines under similar reaction conditions.