Details

Autor(en) / Beteiligte

• Li, Yi-Tien
• Kuo, Duen-Pang
• Tseng, Philip
• Chen, Yung-Chieh
• Cheng, Sho-Jen
• Wu, Changwei W.
• Hsieh, Li-Chun
• Chiang, Yung-Hsiao
• Chung, Hsiao-Wen
• Lui, Yvonne W.
• Chen, Cheng-Yu

Titel

Thalamocortical coherence predicts persistent postconcussive symptoms

Ist Teil von

• Progress in neurobiology, 2023-07, Vol.226, p.102464-102464, Article 102464

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The pathogenetic mechanism of persistent post-concussive symptoms (PCS) following concussion remains unclear. Thalamic damage is known to play a role in PCS prolongation while the evidence and biomarkers that trigger persistent PCS have never been elucidated. We collected longitudinal neuroimaging and behavior data from patients and rodents after concussion, complemented with rodents’ histological staining data, to unravel the early biomarkers of persistent PCS. Diffusion tensor imaging (DTI) were acquired to investigated the thalamic damage, while quantitative thalamocortical coherence was derived through resting-state functional MRI for evaluating thalamocortical functioning and predicting long-term behavioral outcome. Patients with prolonged symptoms showed abnormal DTI-derived indices at the boundaries of bilateral thalami (peri-thalamic regions). Both patients and rats with persistent symptoms demonstrated enhanced thalamocortical coherence between different thalamocortical circuits, which disrupted thalamocortical multifunctionality. In rodents, the persistent DTI abnormalities were validated in thalamic reticular nucleus (TRN) through immunohistochemistry, and correlated with enhanced thalamocortical coherence. Strong predictive power of these coherence biomarkers for long-term PCS was also validated using another patient cohort. Postconcussive events may begin with persistent TRN injury, followed by disrupted thalamocortical coherence and prolonged PCS. Functional MRI-based coherence measures can be surrogate biomarkers for early prediction of long-term PCS. •Thalamic reticular nucleus (TRN) injury persists up to 2 years after concussion.•Persistent postconcussive symptoms (PCS) related to elevated thalamocortical coherence.•TRN injury explains thalamocortical dysfunction and PCS prolongation.•Baseline coherence biomarkers predicts persistent PCS.