Details

Autor(en) / Beteiligte

• Olivito, Ilaria
• Avolio, Ennio
• Minervini, Damiana
• Soda, Teresa
• Rocca, Carmine
• Angelone, Tommaso
• Iaquinta, Francesco Salvatore
• Bellizzi, Dina
• De Rango, Francesco
• Bruno, Rosalinda
• De Bartolo, Loredana
• Alò, Raffaella
• Canonaco, Marcello
• Facciolo, Rosa Maria

Titel

Ketogenic diet ameliorates autism spectrum disorders-like behaviors via reduced inflammatory factors and microbiota remodeling in BTBR T+ Itpr3tf/J mice

Ist Teil von

• Experimental neurology, 2023-08, Vol.366, p.114432-114432, Article 114432

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Autism Spectrum Disorder (ASD) is increasing, but its complete etiology is still lacking. Recently, application of ketogenic diet (KD) has shown to reduce abnormal behaviors while improving psychological/sociological status in neurodegenerative diseases. However, KD role on ASD and underlying mechanism remains unknown. In this work, KD administered to BTBR T+ Itpr3tf/J (BTBR) and C57BL/6J (C57) mice reduced social deficits (p = 0.002), repetitive behaviors (p < 0.001) and memory impairments (p = 0.001) in BTBR. Behavioral effects were related to reduced expression levels of tumor necrosis factor alpha, interleukin-1β, and interleukin-6 in the plasma (p = 0.007; p < 0.001 and p = 0.023, respectively), prefrontal cortex (p = 0.006; p = 0.04 and p = 0.03) and hippocampus (p = 0.02; p = 0.09 and p = 0.03). Moreover, KD accounted for reduced oxidative stress by changing lipid peroxidation levels and superoxide dismutase activity in BTBR brain areas. Interestingly, KD increased relative abundances of putatively beneficial microbiota (Akkermansia and Blautia) in BTBR and C57 mice while reversing the increase of Lactobacillus in BTBR feces. Overall, our findings suggest that KD has a multifunctional role since it improved inflammatory plus oxidative stress levels together with remodeling gut-brain axis. Hence, KD may turn out be a valuable therapeutic approach for ameliorating ASD-like conditions even though more evidence is required to evaluate its effectiveness especially on a long term. •Ketogenic diet reduced social/cognitive deficits as well as repetitive behaviors.•Ketogenic diet mitigated proinflammatory cytokines and oxidative stress levels.•Ketogenic diet increased relative abundances of putatively beneficial microbiota.