Details

Autor(en) / Beteiligte

• Berzin, Tyler M
• Glissen Brown, Jeremy

Titel

Navigating the "Trough of Disillusionment" for CADe Polyp Detection: What Can We Learn About Negative AI Trials and the Physician-AI Hybrid?

Ist Teil von

• The American journal of gastroenterology, 2023-10, Vol.118 (10), p.1743-1745

Ort / Verlag

United States: Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins

Erscheinungsjahr

2023

Beschreibungen/Notizen

• [...]Ahmad et al (11) published an RCT involving 614 patients randomized to receive CADe-assisted colonoscopy vs standard colonoscopy by 8 experts at a UK Bowel Cancer Screening Program and found no difference in ADR but a higher polyp detection rate. [...]we do not have a breakdown of whether provider monitor preference was evenly distributed between the groups, when compared, for instance, with the negative study by Ahmad et al (11) in which providers similarly were able to choose whether to concomitantly use a distal cuff attachment, and, importantly, data were provided to demonstrate even distribution of cuff use between groups. [...]after an interim analysis revealed an estimated recruitment of 6,557 patients per group to power a comparison of APC between groups, the study was terminated early; however, it is unclear whether the prespecified interim analysis was made by the sponsor alone or a Data Safety Monitoring Board. In this study, the authors have provided basic performance characteristics such as per-frame sensitivity and specificity, but it remains impossible to draw robust comparisons between this system and the other CADe systems, given the general opacity of algorithm development, different training data sets, and the absence of standardized approaches to comparing technical performance across systems.