Details

Autor(en) / Beteiligte

• Schupp, Tobias
• Rusnak, Jonas
• Egner-Walter, Sascha
• Ruka, Marinela
• Dudda, Jonas
• Bertsch, Thomas
• Müller, Julian
• Mashayekhi, Kambis
• Tajti, Péter
• Ayoub, Mohammed
• Akin, Ibrahim
• Behnes, Michael

Titel

Prognosis of cardiogenic shock with and without acute myocardial infarction: results from a prospective, monocentric registry

Ist Teil von

• Clinical research in cardiology, 2024-04, Vol.113 (4), p.626-641

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2024

Quelle

SpringerLink

Beschreibungen/Notizen

• Objective The study investigates the prognostic impact of cardiogenic shock (CS) stratified by the presence or absence of acute myocardial infarction (AMI). Background Intensive care unit (ICU) related mortality in CS patients remains unacceptably high despite improvement concerning the treatment of CS patients. Methods Consecutive patients with CS from 2019 to 2021 were included monocentrically. The prognostic impact of CS related to AMI was compared to patients without AMI-related CS. The primary endpoint was 30-day all-cause mortality. Statistical analyses included Kaplan–Meier analyses, multivariable Cox proportional regression analyses and propensity score matching. Results 273 CS patients were included (AMI-related CS: 49%; non-AMI-related CS: 51%). The risk of 30-day all-cause mortality was increased in patients with AMI-related CS (64% vs. 47%; HR = 1.653; 95% CI 1.199–2.281; p  = 0.002), which was still observed after multivariable adjustment (HR = 1.696; 95% CI 1.153–2.494; p  = 0.007). Even after propensity score matching (i.e., 87 matched pairs), AMI was still an independent predictor of 30-day mortality (HR = 1.524; 95% CI 1.020–2.276; p  = 0.040). In contrast, non-ST-segment AMI (NSTEMI) and STEMI were associated with comparable prognosis (log-rank p  = 0.528). Conclusion AMI-related CS was associated with increased 30-day all-cause mortality compared to patients with CS not related to AMI. In contrast, the prognosis of STEMI- and NSTEMI-CS patients was comparable. Graphical abstract