Details

Autor(en) / Beteiligte

• Wang, Qiu-Yue
• Zhang, Lin
• Han, Xiao-Ying
• Wang, Dong-Mei
• Ding, Ming-Long
• Cheng, Dong
• He, Qi-Long
• Liu, Shu-Zhen

Titel

2,3′,4,4′,5-Pentachlorobiphenyl induces mitochondria-dependent apoptosis mediated by AhR/Cyp1a1 in mouse germ cells

Ist Teil von

• Journal of hazardous materials, 2023-03, Vol.445, p.130547-130547, Article 130547

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Polychlorinated biphenyls (PCBs) are environmental organic pollutants widely used in industry that can bioaccumulate and affect the reproductive systems of male animals of different species. 2,3′,4,4′,5-Pentachlorobiphenyl (PCB118) is a representative of the 209 toxic PCB congeners. In this study, male mice were exposed to PCB118 at 0, 50, and 500 μg/kg/day for 35 days beginning 3–4 weeks after birth. The results of the study showed that PCB118 exposure during puberty reduced testicular quality, caused tissue damage, decreased sperm motility and sperm count, and increased malformation and testicular cell apoptosis in mice. Moreover, PCB118 increased the oxidative stress levels in sperm and testicular tissue and the expression of aryl hydrocarbon receptor (AhR) and Cyp1a1 and siginificantly decreased the level of nuclear factor-erythroid 2-related factor 2 (Nrf2). The results indicate that PCB118 can activate the AhR/Cyp1a1 pathway and inhibit Nrf2 expression to aggravate testicular oxidative stress and induce cell apoptosis, resulting in testicular and sperm quality damage. [Display omitted] •Exposure to PCB118 during adolescence has prolonged effects on developmental processes in male mice.•Exposure to PCB118 in male mice during adolescence may alter testicular histology and decrease sperm quality in adult.•PCB118 adolescence exposure alters the expression of AhR, Cyp1a1, and Nrf2 in testes of adult mice.•Adolescent exposure to PCB118 in male mice exacerbates oxidative stress levels in the adult testis and induces cell apoptosis.