Details

Autor(en) / Beteiligte

• Zannoli, Silvia
• Brandolini, Martina
• Marino, Maria Michela
• Denicolò, Agnese
• Mancini, Andrea
• Taddei, Francesca
• Arfilli, Valentina
• Manera, Martina
• Gatti, Giulia
• Battisti, Arianna
• Grumiro, Laura
• Scalcione, Agata
• Dirani, Giorgio
• Sambri, Vittorio

Titel

SARS-CoV-2 coinfection in immunocompromised host leads to the generation of recombinant strain

Ist Teil von

• International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2023, Vol.131, p.65-70

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• OBJECTIVESRecombination related to coinfection is a huge driving force in determining the virus genetic variability, particularly in conditions of partial immune control, leading to prolonged infection. Here, we characterized a distinctive mutational pattern, highly suggestive of Delta-Omicron double infection, in a lymphoma patient. METHODSThe specimen was characterized through a combined approach, analyzing the results of deep sequencing in primary sample, viral culture, and plaque assay. RESULTSBioinformatic analysis on the sequences deriving from the primary sample supports the hypothesis of a double viral population within the host. Plaque assay on viral culture led to the isolation of a recombinant strain deriving from Delta and Omicron lineages, named XS, which virtually replaced its parent lineages within a single viral propagation. CONCLUSIONIt is impossible to establish whether the recombination event happened within the host or in vitro; however, it is important to monitor co-infections, especially in the exceptional intrahost environment of patients who are immunocompromised, as strong driving forces of viral evolution.