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Relationship between short-term self-reported dietary magnesium intake and whole blood ionized magnesium (iMg2+) or serum magnesium (s-Mg) concentrations
Ist Teil von
Annals of medicine (Helsinki), 2023-12, Vol.55 (1), p.2195702-2195702
Ort / Verlag
England: Taylor & Francis
Erscheinungsjahr
2023
Quelle
MEDLINE
Beschreibungen/Notizen
Since we and others have shown that supplemental magnesium raises whole blood ionized magnesium (iMg
2+
) we investigated the relationships between self-reported dietary magnesium intake and concentrations of whole blood iMg
2+
and serum magnesium (s-Mg).
We obtained whole blood iMg
2+
concentrations, as well as s-Mg concentrations, from a pilot, three-arm, randomized, controlled, crossover bioavailability study of magnesium supplements (n = 23; 105 measures). Dietary magnesium intake was assessed using three-day food records and the Nutrition Data System for Research (NDSR, University of Minnesota, MN, USA). Whole blood iMg
2+
was measured with an electrode analyser (NOVA Biochemical, Waltham, MA, USA), whereas s-Mg was measured using atomic absorption spectroscopy. A linear mixed-effects model was employed with dietary magnesium as the outcome variable and iMg
2+
, s-Mg, study treatment and study visit as fixed effects. We adjusted age, gender, race and body mass index covariates.
Values for dietary magnesium, iMg
2+
and s-Mg were 303.8 ± 118.9 mg/day, 1.3 ± 0.1 mg/dL and 2.2 ± 4.1 mg/dL, respectively. No association was found between dietary magnesium intake and iMg
2+
−125 ± 176.95 (p = .49) or s-Mg −9.33 ± 5.04 (p = .08).
Whole blood iMg
2+
and s-Mg concentrations do not reflect short-term self-reported dietary intake in adults. Further research is needed to determine whether blood biomarkers of magnesium may reflect dietary magnesium intake.
Key messages
Dietary intake of magnesium, a shortfall nutrient, may be objectively measured using blood biomarkers of magnesium.
Serum magnesium and whole blood iMg
2+
were not associated with short-term dietary intake of magnesium.