Science (American Association for the Advancement of Science), 2023-04, Vol.380 (6640), p.eadc9498-eadc9498
2023
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Details
- Autor(en) / Beteiligte
- Titel
- Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses
- Ist Teil von
- Science (American Association for the Advancement of Science), 2023-04, Vol.380 (6640), p.eadc9498-eadc9498
- Ort / Verlag
- United States: The American Association for the Advancement of Science
- Erscheinungsjahr
- 2023
- Quelle
- Science Online_科学在线
- Beschreibungen/Notizen
- Despite the vast diversity of the antibody repertoire, infected individuals often mount antibody responses to precisely the same epitopes within antigens. The immunological mechanisms underpinning this phenomenon remain unknown. By mapping 376 immunodominant "public epitopes" at high resolution and characterizing several of their cognate antibodies, we concluded that germline-encoded sequences in antibodies drive recurrent recognition. Systematic analysis of antibody-antigen structures uncovered 18 human and 21 partially overlapping mouse germline-encoded amino acid-binding (GRAB) motifs within heavy and light V gene segments that in case studies proved critical for public epitope recognition. GRAB motifs represent a fundamental component of the immune system's architecture that promotes recognition of pathogens and leads to species-specific public antibody responses that can exert selective pressure on pathogens.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.adc9498Titel-ID: cdi_proquest_miscellaneous_2798708611
- Format
- –
- Schlagworte
- Amino acid composition, Amino Acid Motifs, Amino acids, Animals, Antibodies, Antibody Formation, Antigens, Binding, Chains, Coevolution, Complementarity-determining region 3, Composition, Conserved sequence, Deoxyribonucleic acid, DNA, Epitope Mapping, Epitopes, Germ Cells, Host-Pathogen Interactions - genetics, Host-Pathogen Interactions - immunology, Humans, Humoral immunity, Immune response (humoral), Immunodominant Epitopes - chemistry, Immunodominant Epitopes - genetics, Immunoglobulin Heavy Chains - genetics, Immunoglobulin Heavy Chains - immunology, Immunoglobulin Light Chains - genetics, Immunoglobulin Light Chains - immunology, Light chains, Lymphocytes B, Lysine, Mice, Pathogens, Peptides, Phage display, Phages, Proteins, Receptors, Recognition, Recombination, Segments, Species, Structural analysis, Structural Analysis (Linguistics), Structural Analysis (Science)