Details

Autor(en) / Beteiligte

• Chew, Siu‐Jun
• Low, Kelly BB
• Chong, Chia‐Yin
• Maiwald, Matthias
• Thoon, Koh‐Cheng
• Ong, Rina YL
• Yung, Chee‐Fu
• Li, Jiahui
• Nadua, Karen D
• Kam, Kai‐Qian
• Tan, Henry KK
• Lian, Derrick WQ
• Tan, Leon YR
• Tan, Natalie WH

Titel

Paediatric actinomycosis: A 16‐year, single‐institution retrospective review of cases

Ist Teil von

• Journal of paediatrics and child health, 2023-06, Vol.59 (6), p.833-839

Ort / Verlag

Australia: John Wiley & Sons Australia, Ltd

Erscheinungsjahr

2023

Quelle

Wiley

Beschreibungen/Notizen

• Aim Actinomycosis is a rare subacute to chronic granulomatous infection which can mimic other infectious or malignant diseases. This study examined the epidemiology and treatment outcome of actinomycosis in children. Methods A retrospective study on children admitted for actinomycosis in a tertiary paediatric hospital in Singapore, from January 2004 to December 2020. Clinical profile, therapeutic interventions and outcomes were examined. Results A total of 10 patients were identified; 7 were female. The median age at first presentation was 9.8 years (range 4.7–15.7). The most common presenting symptom was fever (n = 6, 60%), followed by facial or neck swelling (n = 3, 30%) and ear pain (n = 3, 30%). Actinomycosis occurred predominantly in the orocervicofacial region (n = 6, 60%). Four patients (40%) had preceding dental infections in the form of dental caries or gingivitis. One patient had poorly controlled insulin‐dependent diabetes mellitus. Actinomycosis was confirmed via culture in four patients, histopathology in four patients and both methods in two patients. All except one patient (n = 9, 90%) underwent surgical procedures. All patients received ampicillin or amoxicillin/clavulanate or other beta‐lactams, for a median duration of 6.5 months (range 1.5–14). Complications included osteomyelitis (n = 4, 40%), mastoiditis (n = 2, 20%), brain abscess (n = 1, 10%) and recurrent neck abscess (n = 1, 10%). There was no mortality and all patients achieved complete resolution. Conclusions Paediatric actinomycosis was rare in our 16‐year review, but had a high complication rate. It can occur in immunocompetent patients, and dental infection was the predominant risk factor identified. Prognosis was excellent after surgical intervention and appropriate antimicrobial therapy.