Details

Autor(en) / Beteiligte

• wei, Long
• Qi, Xueyu
• Yu, Xueli
• Zheng, Yanghao
• Luo, Xing
• Wei, Yingying
• Ni, Peiyan
• Zhao, Liansheng
• Wang, Qiang
• Ma, Xiaohong
• Deng, Wei
• Guo, Wanjun
• Hu, Xun
• Li, Tao

Titel

3,4-Dihydrobenzo[e][1,2,3]oxathiazine 2,2-dioxide analogs act as potential AMPA receptor potentiators with antidepressant activity

Ist Teil von

• European journal of medicinal chemistry, 2023-05, Vol.251, p.115252-115252, Article 115252

Ort / Verlag

France: Elsevier Masson SAS

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Major depressive disorder is a common psychiatric disorder, with ∼30% of patients suffering from treatment-resistant depression. Based on preclinical studies on ketamine, α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) activation may be a promising therapeutic approach. In this study, we synthesized a series of novel 3,4-dihydrobenzo[e][1,2,3]oxathiazine 2,2-dioxide analogs and analyzed their potential as AMPAR potentiators. Compounds 5aa and 7k exhibited high potentiation with little agonist activity in a high-throughput screen using a calcium influx assay in cultured hippocampal primary neurons. In rats, compound 7k had better pharmacokinetic properties and oral bioavailability (F = 67.19%); it also exhibited an acceptable safety profile in vital internal organs based on hematoxylin and eosin staining. We found that 7k produced a rapid antidepressant-like effect in chronic restraint stress-induced mice 1 h after intraperitoneal administration. Our study presented a series of novel AMPAR potentiators and identified 7k as a promising drug-like candidate against major depressive disorders. [Display omitted] •New 3,4-dihydrobenzo[e] [1–3]oxathiazine 2,2-dioxide analogs as AMPAR potentiators.•Good performance in oral bioavailability and blood-brain barrier penetration.•Antidepressant-like effect in mice depressive-like model.•No toxicity in vital internal organs at 8-fold of antidepressant dose.