Details

Autor(en) / Beteiligte

• Yuan, Y H
• Xu, P P
• Xu, Y Y
• Liu, S
• Shao, X Y
• Zhang, W J
• Gong, L
• Zhou, M
• Chen, B
• Zhou, R F

Titel

Analysis of the effects of low/intermediate dose of coagulation factor Ⅷ on 30 adult patients with severe hemophilia A in a single center

Ist Teil von

• Zhōnghuá xuèyèxué zázhì, 2023-01, Vol.44 (1), p.38-42

Ort / Verlag

China

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• To evaluate the clinical effects of low- and intermediate-dose factor Ⅷ (F Ⅷ) prophylaxis in Chinese adult patients with severe hemophilia A. Thirty adult patients with severe hemophilia A who received low- ( =20) /intermediate-dose ( =10) F Ⅷ prophylaxis at Nanjing Drum Tower Hospital affiliated with Nanjing University Medical College were included in the study. The annual bleeding rate (ABR), annual joint bleeding rate (AJBR), number of target joints, functional independence score of hemophilia (FISH), quality of life score, and health status score (SF-36) before and after preventive treatment were retrospectively analyzed and compared. The median follow-up was 48 months. Compared with on-demand treatment, low- and intermediate-dose prophylaxis significantly reduced ABR, AJBR, and the number of target joints ( <0.05) ; the improvement in the intermediate-dose prophylaxis group was better than that in the low-dose prophylaxis group ( <0.05). Compared with on-demand treatment, the FISH score, quality of life