Details

Autor(en) / Beteiligte

• Chen, Xiang-Long
• Yang, Dong-Sheng
• Tang, Bo-Cheng
• Wu, Chun-Yan
• Wang, Huai-Yu
• Ma, Jin-Tian
• Zhuang, Shi-Yi
• Yu, Zhi-Cheng
• Wu, Yan-Dong
• Wu, An-Xin

Titel

Direct Hydrodefluorination of CF3‑Alkenes via a Mild SN2′ Process Using Rongalite as a Masked Proton Reagent

Ist Teil von

• Organic letters, 2023-04, Vol.25 (13), p.2294-2299

Ort / Verlag

American Chemical Society

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A concise and efficient hydrodefluorination process was developed for the synthesis of gem-difluoroalkenes. This reaction employs rongalite as a masked proton source and does not require any additional catalysts or reductants. Notably, trifluoromethyl alkenes having both terminal and internal double bonds are compatible with this process, allowing for a wider range of substrates. The successful late-stage functionalizations of pharmaceuticals and gram-scale syntheses were used to demonstrate the viability of this method.