Details

Autor(en) / Beteiligte

• Oang, Key Young
• Park, Sungjun
• Moon, Jiwon
• Park, Eunji
• Lee, Hyun Kyung
• Sato, Tokushi
• Nozawa, Shunsuke
• Adachi, Shin-ichi
• Kim, Joonghan
• Kim, Jeongho
• Sohn, Jeong-Hun
• Ihee, Hyotcherl

Titel

Extracting Kinetics and Thermodynamics of Molecules without Heavy Atoms via Time-Resolved Solvent Scattering Signals

Ist Teil von

• The journal of physical chemistry letters, 2023-04, Vol.14 (13), p.3103-3110

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Time-resolved X-ray liquidography (TRXL) has emerged as a powerful technique for studying the structural dynamics of small molecules and macromolecules in liquid solutions. However, TRXL has limited sensitivity for small molecules containing light atoms only, whose signal has lower contrast compared with the signal from solvent molecules. Here, we present an alternative approach to bypass this limitation by detecting the change in solvent temperature resulting from a photoinduced reaction. Specifically, we analyzed the heat dynamics of TRXL data obtained from p-hydroxyphenacyl diethyl phosphate (HPDP). This analysis enabled us to experimentally determine the number of intermediates and their respective enthalpy changes, which can be compared to theoretical enthalpies to identify the intermediates. This work demonstrates that TRXL can be used to uncover the kinetics and reaction pathways for small molecules without heavy atoms even if the scattering signal from the solute molecules is buried under the strong solvent scattering signal.