Details

Autor(en) / Beteiligte

• Zhang, Yixiao
• Xia, Yang
• Chang, Qing
• Ji, Chao
• Zhao, Yuhong
• Zhang, Hehua

Titel

Exposure to ambient air pollution and metabolic kidney diseases: evidence from the Northeast China Biobank

Ist Teil von

• Nephrology, dialysis, transplantation, 2023-09, Vol.38 (10), p.2222-2231

Ort / Verlag

England: Oxford University Press

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• ABSTRACT Background At present, there is no epidemiological evidence of the association between metabolic kidney diseases (MKD) and exposure to air pollution. Methods We investigated the association between exposure to long-term air pollution and the risk of developing MKD using samples from the Northeast China Biobank. Results Data from 29 191 participants were analyzed. MKD prevalence was 3.23%. Every standard deviation increment in PM2.5 increased the risk of MKD [odds ratio (OR) = 1.37, 95% confidence interval (CI) 1.19–1.58), diabetic kidney disease (DKD) (OR = 2.03, 95% CI 1.52–2.73), hypertensive kidney disease (BKD) (OR = 1.31, 95% CI 1.11–1.56), hyperlipidemic kidney disease (PKD) (OR = 1.39, 95% CI 1.19–1.63) and obese kidney disease (OKD) (OR = 1.34, 95% CI 1.00–1.81). PM10 increased the risk of MKD (OR = 1.42, 95% CI 1.20–1.67), DKD (OR = 1.38, 95% CI 1.03–1.85), BKD (OR = 1.30, 95% CI 1.07–1.58) and PKD (OR = 1.50, 95% CI 1.26–1.80). Sulfur dioxide increased the risk of MKD (OR = 1.57, 95% CI 1.34–1.85), DKD (OR = 1.81, 95% CI 1.36–2.40), BKD (OR = 1.44, 95% CI 1.19–1.74) and PKD (OR = 1.72, 95% CI 1.44–2.04). Ozone decreased the risk of PKD (OR = 0.83, 95% CI 0.70–0.99). Age, ethnicity and air pollution interacted to affect the risk of MKD, BKD and PKD. Associations between air pollution and CKD or metabolic disease were weaker than those with MKD. The association between air pollution and MKD became stronger when compared with participants with non-metabolic disease. Conclusions Air pollution may cause MKD or facilitate the progression from metabolic disease to renal failure. Graphical Abstract Graphical Abstract