Details

Autor(en) / Beteiligte

• Gao, Cong-Hui
• Li, Ji-Mei
• Xu, Bo
• An, Zhi-Fan
• Wang, Zhi-Jie
• Chen, Xiao-Qi
• Zhang, Jia-Yu
• Wei, Deng-Bang

Titel

Responses of blood parameters and hemoglobin subtypes in plateau zokors and plateau pikas to different altitude habitats

Ist Teil von

• Sheng li hsüeh pao, 2023-02, Vol.75 (1), p.69-81

Ort / Verlag

China

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• The plateau zokor (Myospalax baileyi) and plateau pika (Ochotona curzoniae) are native species unique to the Qinghai-Tibetan Plateau with successful adaptation to the hypoxic environment. In this study, the number of red blood cells, hemoglobin concentration, mean hematocrit and mean volume of red blood cells were measured in plateau zokors and plateau pikas at different altitudes. Hemoglobin subtypes of two plateau animals were identified by mass spectrometry sequencing. The forward selection sites in two animals' hemoglobin subunits were analyzed by PAML4.8 program. Homologous modeling was used to analyze the effect of forward selection sites on the affinity of hemoglobin to oxygen. The adapting strategies of plateau zokors and plateau pikas to hypoxia at different altitudes were analyzed through comparing blood parameters between the two species. The results indicated that, with increasing altitudes, plateau zokors responded to hypoxia by increasing red blood cell count and decreasing red blood cell volume