Details

Autor(en) / Beteiligte

• Chalfun, Georgia
• Araújo Brasil, Aline de
• Paravidino, Vitor Barreto
• Soares-Lima, Sheila Coelho
• Souza Almeida Lopes, Monique de
• Santos Salú, Margarida Dos
• Barbosa E Dos Santos, Paulo Victor
• P da Cunha Trompiere, Ana Carolina
• Vieira Milone, Leo Travassos
• Rodrigues-Santos, Gustavo
• Genuíno de Oliveira, Mariana Barros
• Robaina, Jaqueline Rodrigues
• Lima-Setta, Fernanda
• Reis, Marcelo Martins
• Ledo Alves da Cunha, Antônio José
• Prata-Barbosa, Arnaldo
• de Magalhães-Barbosa, Maria Clara

Titel

NR3C1 gene methylation and cortisol levels in preterm and healthy full-term infants in the first 3 months of life

Ist Teil von

• Epigenomics, 2022-12, Vol.14 (24), p.1545-1561

Ort / Verlag

England

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Taylor & Francis Journals Auto-Holdings Collection

Beschreibungen/Notizen

• To describe exon-1 methylation and cortisol levels in newborns. Preterm ≤1500 g and full-term infants were included. Samples were collected at birth and at days 5, 30 and 90 (or at discharge). 46 preterm and 49 full-term infants were included. Methylation was stable over time in full-term infants (p = 0.3116) but decreased in preterm infants (p = 0.0241). Preterm infants had higher cortisol levels on the fifth day, while full-term infants showed increasing levels (p = 0.0177) over time. Hypermethylated sites in at birth and higher cortisol levels on day 5 suggest that prematurity, reflecting prenatal stress, affects the epigenome. Methylation decrease over time in preterm infants suggests that postnatal factors may modify the epigenome, but their role needs to be clarified.