Details

Autor(en) / Beteiligte

• Sheikhbahaei, Sara
• Bello Martinez, Ricardo
• Markowski, Mark C.
• Eisenberger, Mario A.
• Pienta, Kenneth J.
• Reyes, Diane
• Brosnan, Mary Katherine
• Spiro, Ergi
• AbdAllah, Rehab
• Holt, Daniel P.
• Dannals, Robert F.
• Werner, Rudolf A.
• Pomper, Martin G.
• Gorin, Michael A.
• Solnes, Lilja B.
• Rowe, Steven P.

Titel

Multi-timepoint imaging with PSMA-targeted [18F]F-Florastamin PET/CT: lesion detection and comparison to conventional imaging

Ist Teil von

• Annals of nuclear medicine, 2023-04, Vol.37 (4), p.246-254

Ort / Verlag

Singapore: Springer Nature Singapore

Erscheinungsjahr

2023

Quelle

SpringerLink

Beschreibungen/Notizen

• Objective The aims of this study were to investigate the utility of [ 18 F]F-Florastamin, a novel prostate-specific membrane antigen (PSMA)-targeted PET radiotracer with facile radiochemistry, relative to the conventional imaging for the detection of sties of disease and evaluate the effect of multi-timepoint imaging with [ 18 F]F-Florastamin PET on lesion detectability. Methods Eight prostate cancer patients with known or suspected recurrence who underwent [ 18 F]F-Florastamin PET/CT at 1-h and 2-h imaging time-points were included in this prospective pilot study. [ 18 F]F-Florastamin PET images were interpreted visually and quantitatively at both time points and compared with CIM. Results [ 18 F]F-Florastamin PET was superior to CT in the detection of active osseous metastases and small-sized metastatic lymph nodes that do not fall under the anatomic imaging size criteria for metastasis. Multi-timepoint imaging showed a significant reduction in the blood pool, bone marrow and muscular uptake, and increase in liver uptake over time. There is a significant improvement in tumor-to-background ratio (TBR) at the 2-h imaging time-point ( P  = 0.04). The mean percentage change in TBR at 2-h was 21% (SD = 0.31). Conclusions [ 18 F]F-Florastamin is a promising new radioligand for PSMA-targeted PET with suitable lesion detectability and high TBR at both time points.