UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 5 von 37
Datensatz exportieren als...
BibTeX
Duodenal alpha‐Synuclein Pathology and Enteric Gliosis in Advanced Parkinson's Disease
Movement disorders, 2023-05, Vol.38 (5), p.885-894
Emmi, Aron
Sandre, Michele
Russo, Francesco Paolo
Tombesi, Giulia
Garrì, Federica
Campagnolo, Marta
Carecchio, Miryam
Biundo, Roberta
Spolverato, Gaya
Macchi, Veronica
Savarino, Edoardo
Farinati, Fabio
Parchi, Piero
Porzionato, Andrea
Bubacco, Luigi
De Caro, Raffaele
Kovacs, Gabor G.
Antonini, Angelo
2023
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Emmi, Aron
Sandre, Michele
Russo, Francesco Paolo
Tombesi, Giulia
Garrì, Federica
Campagnolo, Marta
Carecchio, Miryam
Biundo, Roberta
Spolverato, Gaya
Macchi, Veronica
Savarino, Edoardo
Farinati, Fabio
Parchi, Piero
Porzionato, Andrea
Bubacco, Luigi
De Caro, Raffaele
Kovacs, Gabor G.
Antonini, Angelo
Titel
Duodenal alpha‐Synuclein Pathology and Enteric Gliosis in Advanced Parkinson's Disease
Ist Teil von
Movement disorders, 2023-05, Vol.38 (5), p.885-894
Ort / Verlag
Hoboken, USA: John Wiley & Sons, Inc
Erscheinungsjahr
2023
Quelle
Wiley Blackwell Single Titles
Beschreibungen/Notizen
Background The role of the gut‐brain axis has been recently highlighted as a major contributor to Parkinson's disease (PD) physiopathology, with numerous studies investigating bidirectional transmission of pathological protein aggregates, such as α‐synuclein (αSyn). However, the extent and the characteristics of pathology in the enteric nervous system have not been fully investigated. Objective We characterized αSyn alterations and glial responses in duodenum biopsies of patients with PD by employing topography‐specific sampling and conformation‐specific αSyn antibodies. Methods We examined 18 patients with advanced PD who underwent Duodopa percutaneous endoscopic gastrostomy and jejunal tube procedure, 4 untreated patients with early PD (disease duration <5 years), and 18 age‐ and ‐sex‐matched healthy control subjects undergoing routine diagnostic endoscopy. A mean of four duodenal wall biopsies were sampled from each patient. Immunohistochemistry was performed for anti‐aggregated αSyn (5G4) and glial fibrillary acidic protein antibodies. Morphometrical semiquantitative analysis was performed to characterize αSyn‐5G4+ and glial fibrillary acidic protein–positive density and size. Results Immunoreactivity for aggregated α‐Syn was identified in all patients with PD (early and advanced) compared with controls. αSyn‐5G4+ colocalized with neuronal marker β‐III‐tubulin. Evaluation of enteric glial cells demonstrated an increased size and density when compared with controls, suggesting reactive gliosis. Conclusions We found evidence of synuclein pathology and gliosis in the duodenum of patients with PD, including early de novo cases. Future studies are required to evaluate how early in the disease process duodenal pathology occurs and its possible contribution to levodopa effect in chronic patients. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Sprache
Englisch
Identifikatoren
ISSN: 0885-3185
eISSN: 1531-8257
DOI: 10.1002/mds.29358
Titel-ID: cdi_proquest_miscellaneous_2780483407
Format
–
Schlagworte
alpha‐synuclein
,
Antibodies
,
Biopsy
,
Cell size
,
Duodenum
,
Endoscopy
,
Enteric nervous system
,
gastrointestinal biopsies
,
Glial cells
,
Glial fibrillary acidic protein
,
Gliosis
,
Immunohistochemistry
,
Levodopa
,
Movement disorders
,
Neurodegenerative diseases
,
Neuronal-glial interactions
,
neuropathology
,
Ostomy
,
Parkinson's disease
,
Pathology
,
Proteins
,
Small intestine
,
Synuclein
,
Tubulin
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX