Details

Autor(en) / Beteiligte

• Wang, Weihong
• Kim, Seungjin
• Vu, Thi Hanh Nguyen
• Quach, Ngoc Tung
• Oh, Eunseok
• Park, Kyu-Hyung
• Park, Chanyoon
• Cho, Youbin
• Jang, Hyeseon
• Roh, Eun
• Lee, JunI
• Kang, Eunmo
• Han, SongJoo
• Phi, Quyet-Tien
• Kang, Heonjoong

Titel

Bioactive Piperazic Acid-Bearing Cyclodepsipeptides, Lydiamycins E–H, from an Endophytic Streptomyces sp. Associated with Cinnamomum cassia

Ist Teil von

• Journal of natural products (Washington, D.C.), 2023-04, Vol.86 (4), p.751-758

Ort / Verlag

United States: American Chemical Society and American Society of Pharmacognosy

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• A chemical investigation of the endophytic Streptomyces sp. HBQ95, associated with the medicinal plant Cinnamomum cassia Presl, enabled the discovery of four new piperazic acid-bearing cyclodepsipeptides, lydiamycins E–H (1–4), and one known compound (lydiamycin A). Their chemical structures, including absolute configurations, were defined by a combination of spectroscopic analyses and multiple chemical manipulations. Lydiamycins F–H (2–4) and A (5) exhibited antimetastatic activity against PANC-1 human pancreatic cancer cells without significant cytotoxicity.