Details

Autor(en) / Beteiligte

• Falcone, Marco
• Tiseo, Giusy
• Carbonara, Sergio
• Marino, Andrea
• Di Caprio, Giovanni
• Carretta, Anna
• Mularoni, Alessandra
• Mariani, Michele Fabiano
• Maraolo, Alberto Enrico
• Scotto, Riccardo
• Dalfino, Lidia
• Corbo, Lorenzo
• Macera, Margherita
• Medaglia, Alice Annalisa
• d’Errico, Maria Luca
• Gioè, Claudia
• Sgroi, Christian
• Del Vecchio, Rosa Fontana
• Ceccarelli, Giancarlo
• Albanese, Antonio
• Buscemi, Calogero
• Talamanca, Simona
• Raponi, Giammarco
• Foti, Giuseppe
• De Stefano, Giulio
• Franco, Antonina
• Iacobello, Carmelo
• Corrao, Salvatore
• Morana, Uccio
• Pieralli, Filippo
• Gentile, Ivan
• Santantonio, Teresa
• Cascio, Antonio
• Coppola, Nicola
• Cacopardo, Bruno
• Farcomeni, Alessio
• Venditti, Mario
• Menichetti, Francesco

Titel

Mortality Attributable to Bloodstream Infections Caused by Different Carbapenem-Resistant Gram-Negative Bacilli: Results From a Nationwide Study in Italy (ALARICO Network)

Ist Teil von

• Clinical infectious diseases, 2023-06, Vol.76 (12), p.2059-2069

Ort / Verlag

US: Oxford University Press

Erscheinungsjahr

2023

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Background Our aim was to analyze mortality attributable to carbapenem-resistant (CR) gram-negative bacilli (GNB) in patients with bloodstream infections (BSIs). Methods Prospective multicentric study including patients with GNB-BSI from 19 Italian hospitals (June 2018–January 2020). Patients were followed-up to 30 days. Primary outcomes were 30-day mortality and attributable mortality. Attributable mortality was calculated in the following groups: Klebsiella pneumoniae carbapenemase (KPC)–producing Enterobacterales, metallo-β-lactamases (MBL)–producing Enterobacterales, CR-Pseudomonas aeruginosa (CRPA), CR-Acinetobacter baumannii (CRAB). A multivariable analysis with hospital fixed-effect was built to identify factors associated with 30-day mortality. Adjusted OR (aORs) were reported. Attributable mortality was calculated according to the DRIVE-AB Consortium. Results Overall, 1276 patients with monomicrobial GNB BSI were included: 723/1276 (56.7%) carbapenem-susceptible (CS)-GNB, 304/1276 (23.8%) KPC-, 77/1276 (6%) MBL-producing CRE, 61/1276 (4.8%) CRPA, and 111/1276 (8.7%) CRAB BSI. Thirty-day mortality in patients with CS-GNB BSI was 13.7% compared to 26.6%, 36.4%, 32.8% and 43.2% in patients with BSI by KPC-CRE, MBL-CRE, CRPA and CRAB, respectively (P < .001). On multivariable analysis, age, ward of hospitalization, SOFA score, and Charlson Index were factors associated with 30-day mortality, while urinary source of infection and early appropriate therapy resulted protective factors. Compared to CS-GNB, MBL-producing CRE (aOR 5.86, 95% CI 2.72–12.76), CRPA (aOR 1.99, 95% CI 1.48–5.95) and CRAB (aOR 2.65, 95% CI 1.52–4.61) were significantly associated with 30-day mortality. Attributable mortality rates were 5% for KPC-, 35% for MBL, 19% for CRPA, and 16% for CRAB. Conclusions In patients with BSIs, carbapenem-resistance is associated with an excess of mortality, with MBL-producing CRE carrying the highest risk of death. Evaluation of mortality attributable to antimicrobial resistance is challenging. We calculated attributable mortality in bacteremia by different carbapenem-resistant gram-negative bacilli. Carbapenem resistance is associated with an excess mortality (highest in MBL-producing Enterobacterales) even if active antibiotic therapy is started early.