Details

Autor(en) / Beteiligte

• Devolder, Lindsay
• Pauwels, Ayla
• Van Remoortel, Ann
• Falony, Gwen
• Vieira-Silva, Sara
• Nagels, Guy
• De Keyser, Jacques
• Raes, Jeroen
• D'Hooghe, Marie B.

Titel

Gut microbiome composition is associated with long-term disability worsening in multiple sclerosis

Ist Teil von

• Gut microbes, 2023-12, Vol.15 (1), p.2180316-2180316

Ort / Verlag

United States: Taylor & Francis

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Predicting the long-term outcome of multiple sclerosis (MS) remains an important challenge to this day. As the gut microbiota is emerging as a potential player in MS, we investigated in this study whether gut microbial composition at baseline is related to long-term disability worsening in a longitudinal cohort of 111 MS patients. Fecal samples and extensive host metadata were collected at baseline and 3 months post-baseline, with additional repeated neurological measurements performed over (median) 4.4 y. Worsening (with EDSS-Plus) occurred in 39/95 patients (outcome undetermined for 16 individuals). The inflammation-associated, dysbiotic Bacteroides 2 enterotype (Bact2) was detected at baseline in 43.6% of worsened patients, while only 16.1% of non-worsened patients harbored Bact2. This association was independent of identified confounders, and Bact2 was more strongly associated with EDSS-Plus than neurofilament light chain (NfL) plasma levels. Furthermore, using fecal sampling performed 3 months post-baseline, we observed Bact2 to be relatively stable, suggesting its potential use as a prognostic biomarker in MS clinical practice.