Details

Autor(en) / Beteiligte

• Wang, H.‐B.
• Jia, Y.
• Zhang, C.‐B.
• Zhang, L.
• Li, Y.‐N.
• Ding, J.
• Wu, X.
• Zhang, Z.
• Wang, J.‐H.
• Wang, Y.
• Yan, F.‐X.
• Yuan, S.
• Sessler, D. I.

Titel

A randomised controlled trial of dexmedetomidine for delirium in adults undergoing heart valve surgery

Ist Teil von

• Anaesthesia, 2023-05, Vol.78 (5), p.571-576

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2023

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Summary Dexmedetomidine might reduce delirium after cardiac surgery. We allocated 326 participants to an infusion of dexmedetomidine at a rate of 0.6 μg kg−1 for 10 min and then at 0.4 μg.kg−1.h−1 until the end of surgery; 326 control participants received comparable volumes of saline. We detected delirium in 98/652 (15%) participants during the first seven postoperative days: 47/326 after dexmedetomidine vs. 51/326 after placebo, p = 0.62, adjusted relative risk (95%CI) 0.86 (0.56–1.33), p = 0.51. Postoperative renal impairment (Kidney Disease Improving Global Outcomes stages 1, 2 and 3) was detected in 46, 9 and 2 participants after dexmedetomidine and 25, 7 and 4 control participants, p = 0.040. Intra‐operative dexmedetomidine infusion did not reduce the incidence of delirium after cardiac valve surgery but might impair renal function.