Details

Autor(en) / Beteiligte

• Strobl, Johanna
• Huber, Bettina
• Heredia, Raul Jimenez
• Kirnbauer, Reinhard
• Boztug, Kaan
• Stary, Georg

Titel

Polymerase-δ-deficiency as a novel cause of inborn cancer predisposition associated with human papillomavirus infection

Ist Teil von

• British journal of dermatology (1951), 2023-04, Vol.188 (5), p.684-685

Ort / Verlag

England

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Our study illustrates a predisposition to cancer upon cutaneous β genus human papillomavirus (HPV) infection as part of human polymerase-δ deficiency. In addition, polymerase-δ deficiency infers susceptibility to the development of large cutaneous warts and progression to squamous cell carcinoma associated with HPV63, which usually causes benign papillomas. Our findings warrant close monitoring for viral skin oncogenesis in individuals with syndromic polymerase-δ deficiency.