Details

Autor(en) / Beteiligte

• Xi, Yu-Fei
• Bai, Ming
• Zhang, Xin
• Hou, Zi-Lin
• Lin, Bin
• Yao, Guo-Dong
• Lou, Li-Li
• Wang, Xiao-Bo
• Song, Shao-Jiang
• Huang, Xiao-Xiao

Titel

Insight into tetrahydrofuran lignans from Isatis indigotica fortune with neuroprotective and acetylcholinesterase inhibitor activity

Ist Teil von

• Phytochemistry (Oxford), 2023-04, Vol.208, p.113609-113609, Article 113609

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Nine tetrahydrofuran lignans, including three undescribed spiro-lignans, were isolated from Isatis indigotica Fortune (Brassicaceae). Extensive spectroscopic analyses achieved the structure elucidation of these tetrahydrofuran lignans, and quantum chemical calculation combined with the MAEΔΔδ parameter. Notably, isatispironeols A-B have a unique spiro[dienone-tetrahydrofuran] molecular core. These spiro[dienone-tetrahydrofuran] lignans showed comparable neuroprotective effects as the positive control in the H2O2-induced SH-SY5Y cells model. In addition, (−)-(7R,8S,1′R,7′R,8′R)-isatispironeol A possessed more significant AChE inhibitory activity, further interact sites were also predicted by the in silico assay. Nine tetrahydrofuran lignans, including three undescribed spiro-lignans, were isolated from Isatis indigotica Fortune (Brassicaceae). These undescribed spiro-lignans with a unique spiro[dienone-tetrahydrofuran] molecular core. [Display omitted] •Three undescribed spiro-lignans were isolated from Isatis indigotica Fortune.•The structure elucidation was achieved by quantum chemical calculation.•Isatispironeols A-B have a unique spiro[dienone-tetrahydrofuran] molecular core.•These spiro-lignans showed comparable neuroprotective effects.•(−)-isatispironeol A possessed greater AChE inhibitory activity.