Details

Autor(en) / Beteiligte

• Quaioto, Bárbara Risse
• Borçoi, Aline Ribeiro
• Mendes, Suzanny Oliveira
• Doblas, Paola Cerbino
• dos Santos Vieira, Tamires
• Arantes Moreno, Ivana Alece
• dos Santos, Joaquim Gasparini
• Hollais, André Willian
• Olinda, Amanda Sgrancio
• de Souza, Marcele Lorentz Mattos
• Freitas, Flávia Vitorino
• Pinheiro, Júlia Assis
• Cunha, Ester Ribeiro
• Sorroche, Bruna Pereira
• Arantes, Lídia Maria Rebolho Batista
• Álvares-da-Silva, Adriana Madeira

Titel

Tobacco use modify exon IV BDNF gene methylation levels in depression

Ist Teil von

• Journal of psychiatric research, 2023-03, Vol.159, p.240-248

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• This study aimed to investigate BDNF gene methylation in individuals with depression based on tobacco use. Therefore, 384 adults from southeastern Brazil were recruited to assess depression, socioeconomic status, lifestyle, and methylation by pyrosequencing exon IV promoter region of the BDNF gene. The Generalized Linear Model (GzLM) was used to check the effect of depression, tobacco, and the interaction between depression and tobacco use in methylation levels. In addition, the Kruskal-Wallis test, followed by Dunn's post hoc test, was used to compare methylation levels. Interaction between depression and tobacco use was significant at levels of BDNF methylation in the CpG 5 (p = 0.045), 8 (p = 0.016), 9 (p = 0.042), 10 (p = 0.026) and mean 5–11 (p < 0.001). Dunn's post hoc test showed that individuals with depression and tobacco use compared to those with or without depression who did not use tobacco had lower levels of BDNF methylation in CpG 5, 6, 7, 8, 9, 11, and mean 5–11. Therefore, we suggest that tobacco use appears to interfere with BDNF gene methylation in depressed individuals.