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Persimmon, or sharon fruit (Diospyros kaki), is a sweet tropical fruit from the Ebenaceae tree family. It is commonly cultivated in warm regions of the world, including China, Japan, Brazil, Turkey, and Italy. Although it is widely consumed in industrialized countries owing to its beneficial properties, few cases of allergy to persimmon have been reported. No persimmon allergens have been officially recognized (allergen.org), although 4 allergens have been identified as being involved in isolated allergic reactions, namely, nsLTP, Bet v 1 protein-like, profilin, and isoflavone reductase (the last 3 are recognized in allergome.org). We present 2 case reports of systemic immediate reactions after ingestion of persimmon.