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The spin configuration in a magnet is in general a 'natural' consequence of both the intrinsic properties of the material and the sample dimensions. We demonstrate that this limitation can be overcome in a homogeneous ferromagnetic film by engineering an anisotropy contrast. Substrates with laterally modulated single-crystal and polycrystalline surface regions were used to induce selective epitaxial growth of a ferromagnetic Ni film. The resulting spatially varying magnetic anisotropy leads to regular perpendicular and in-plane magnetic domains, separated by a new type of magnetic domain wall-the 'anisotropy constrained' magnetic wall. Micromagnetic simulations indicate that the wall is asymmetric, has a small out-of-plane component and has no mobility under external perturbation. (Example material: epitaxial Cu/Ni /Cu(001).)