Details

Autor(en) / Beteiligte

• Kempers, Eva K.
• van Kwawegen, Calvin B.
• de Meris, Joke
• Spaander, Manon C.W.
• Schols, Saskia E.M.
• Ypma, Paula F.
• Heubel-Moenen, Floor C.J.I.
• van Vulpen, Lize F.D.
• Coppens, Michiel
• van der Bom, Johanna G.
• Fijnvandraat, Karin
• Meijer, Karina
• Eikenboom, Jeroen
• Gouw, Samantha C.
• Leebeek, Frank W.G.
• Kruip, Marieke J.H.A.

Titel

Colorectal cancer screening in patients with inherited bleeding disorders: high cancer detection rate in hemophilia patients

Ist Teil von

• Journal of thrombosis and haemostasis, 2023-05, Vol.21 (5), p.1177-1188

Ort / Verlag

England: Elsevier Inc

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• The population-based colorectal cancer (CRC) screening program in individuals aged 55 to 75 years in the Netherlands uses fecal immunochemical testing (FIT), to detect hemoglobin in feces, followed by colonoscopy in individuals with a positive FIT. The objectives of this study are to assess the false-positive rate, detection rate, and positive predictive value of FIT for CRC and advanced adenoma (AA) in patients with Von Willebrand disease (VWD) or hemophilia. We performed a multicenter, nationwide cross-sectional study embedded in 2 nationwide studies on VWD and hemophilia in the Netherlands. In total, 493 patients with hemophilia (n = 329) or VWD (n = 164) were included, of whom 351 patients participated in the CRC screening program (71.2%). FIT positivity and false-positive rate in patients with hemophilia and VWD were significantly higher than those in the general population (14.8% vs. 4.3%, p < .001 and 10.3% vs. 2.3%, p <.001, respectively). In patients with hemophilia, the detection rate of CRC/AA was significantly higher than that in the general male population (4.5% vs. 1.8%, p = .02), and the positive predictive value of FIT for CRC/AA was comparable (32.3% vs. 39.7%, n.s.). In patients with VWD, the detection rate was similar to that of the general population (0.8% vs. 1.4%, n.s.), whereas the positive predictive value was significantly lower than that in the general population (6.3% vs. 36.8%, p = .02). This study indicates that despite a high false-positive rate of FIT in patients with inherited bleeding disorders, the detection rate of CRC and/or AA in hemophilia patients is high. FIT performs different in patients with hemophilia or VWD compared with the general population. •We studied the fecal immunochemical test (FIT) performance in inherited bleeding disorders.•The false-positive rate of FIT in patients with inherited bleeding disorders is high.•Colorectal cancer detection rate in hemophilia patients was higher than that in the general population.•The positive predictive value of FIT was low in patients with Von Willebrand disease.