UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 7 von 148
Datensatz exportieren als...
BibTeX
First Clinical Report on the Treatment of Parkinson's Disease with Fetal Midbrain Precursor Cells
Movement disorders, 2023-04, Vol.38 (4), p.589-603
Kim, Joopyoung
Inbo, Han
Kim, Hyun Sook
Kim, WonChan
Jang, Su Jin
Min, Kyunghoon
Kim, Sang Heum
Bae, Sang‐Hun
Jeong, Yun‐Hwa
Kim, Borah
Kim, Chul
Schwarz, Sigrid C.
Schwarz, Johannes
Cho, Kyung Gi
Chung, Sang‐Sup
Moon, Jisook
2023
Details
Autor(en) / Beteiligte
Kim, Joopyoung
Inbo, Han
Kim, Hyun Sook
Kim, WonChan
Jang, Su Jin
Min, Kyunghoon
Kim, Sang Heum
Bae, Sang‐Hun
Jeong, Yun‐Hwa
Kim, Borah
Kim, Chul
Schwarz, Sigrid C.
Schwarz, Johannes
Cho, Kyung Gi
Chung, Sang‐Sup
Moon, Jisook
Titel
First Clinical Report on the Treatment of Parkinson's Disease with Fetal Midbrain Precursor Cells
Ist Teil von
Movement disorders, 2023-04, Vol.38 (4), p.589-603
Ort / Verlag
Hoboken, USA: John Wiley & Sons, Inc
Erscheinungsjahr
2023
Link zum Volltext
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Background Because human fetal ventral mesencephalic tissue grafts provide promising results in ameliorating Parkinson's disease–implicated motor dysfunctions, human fetal midbrain‐derived dopamine neuronal precursor cells are considered good candidates for cell‐based therapy for Parkinson's disease in that large quantities of cells can be supplied through a good manufacturing practice–compliant system. Objective We conducted a prospective, phase I/IIa, dose‐escalation, open‐label “first‐in‐human” clinical trial with fetal neural precursor cells to assess their safety and therapeutic efficacy in patients with idiopathic Parkinson's disease. Methods Fifteen patients were assigned to receive three different doses of cells (4 × 106, 12 × 106, and 40 × 106 cells) and completed a 12‐month follow‐up. The primary outcome was safety, by measuring the presence of grade 3 or higher cells according to National Cancer Institute guidelines and any contaminated cells. Secondary outcomes assessed motor and neurocognitive function, as well as the level of dopamine transporters, by positron emission tomography–computed tomography. Results Although a pronation‐supination and hand/arm movement performance was remarkably enhanced in all three groups (all P < 0.05), the medium‐ and high‐dose‐treated groups exhibited significant improvement in Unified Parkinson's Disease Rating Scale Part III only up to 26.16% and 40%, respectively, at 12 months after transplantation without any serious clinical complications or graft‐induced dyskinesia in all patients. However, the motor improvements did not correlate with increase in the dopamine transporter on positron emission tomography images. Conclusions Our results primarily demonstrate the safety and plausible dose‐dependent efficacy of human fetal midbrain‐derived dopamine neuronal precursor cells for idiopathic Parkinson's disease. © 2023 International Parkinson and Movement Disorder Society.
Sprache
Englisch
Identifikatoren
ISSN: 0885-3185
eISSN: 1531-8257
DOI: 10.1002/mds.29316
Titel-ID: cdi_proquest_miscellaneous_2769375617
Format
–
Schlagworte
Arm
,
clinical trial
,
Cognition
,
Computed tomography
,
Dopamine
,
Dopamine transporter
,
Dyskinesia
,
efficacy
,
Fetuses
,
human fetal mesencephalic dopamine neural precursor cells
,
Humans
,
Mesencephalon
,
Mesencephalon - diagnostic imaging
,
Movement disorders
,
Neural Stem Cells
,
Neurodegenerative diseases
,
Parkinson Disease - drug therapy
,
Parkinson Disease - therapy
,
Parkinson's disease
,
Patients
,
Positron emission tomography
,
Prospective Studies
,
Safety
,
Tomography
,
Tomography, X-Ray Computed
,
Transplantation
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX