Details

Autor(en) / Beteiligte

• Peng, Xingrong
• Luo, Rongcan
• Ran, Xiaoqian
• Guo, Yarong
• Yao, Yong-Gang
• Qiu, Minghua

Titel

Ganoapplins A and B with an unprecedented 6/6/6/5/6-fused pentacyclic skeleton from Ganoderma inhibit Tau pathology through activating autophagy

Ist Teil von

• Bioorganic chemistry, 2023-03, Vol.132, p.106375-106375, Article 106375

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• [Display omitted] •Ganoapplins A and B (1 and 2) are the first example of GTs with a 6/6/6/5/6 pentacyclic skeleton containing an unprecedented aromatic E ring.•Ganoapplins A and B (1 and 2) are found to have significant inhibition against pathogenic Tau protein through activating autophagy.•Our study enriches the skeleton diversity of lanostane-type triterpenoids and provides structural model for the discovery of anti-AD’ agent. Ganoapplins A and B (1 and 2) with a 6/6/6/5/6-fused pentacyclic skeleton containing an aromatic E ring, were obtained from Ganoderma applanatum. Their structures were established through extensive spectroscopic analyses, quantum chemical calculations, including calculated chemical shifts with DP4 + analysis and electronic circular dichroism (ECD). A plausible biosynthetic pathway for 1 and 2 was proposed. Furthermore, their roles in activating autophagy were investigated and the cellular assays showed that 1 and 2 can inhibit tau pathology by inducing autophagy, suggesting their potential against Alzheimer’s disease (AD).