Details

Autor(en) / Beteiligte

• Gómez-Vaquero, Carmen
• Hernández, José Luis
• Olmos, José Manuel
• Cerdà, Dacia
• Calleja, Cristina Hidalgo
• López, Juan Antonio Martínez
• Arboleya, Luis
• del Rey, Francisco Javier Aguilar
• Pardo, Silvia Martinez
• Vilamajó, Inmaculada Ros
• Armangué, Xavier Surís
• Grados, Dolors
• Audera, Chesús Beltrán
• Suero-Rosario, Evelyn
• Gracia, Inmaculada Gómez
• Chamizo, Asunción Salmoral
• Martín-Esteve, Irene
• Florez, Helena
• Naranjo, Antonio
• Castañeda, Santos
• Bruno, Soledad Ojeda
• Carazo, Sara García
• Garcia-Vadillo, Alberto
• Vives, Laura López
• Martínez-Ferrer, Àngels
• Paños, Helena Borrell
• Acín, Pilar Aguado
• Castellanos-Moreira, Raul
• Satorra, Pau
• Tebé, Cristian
• Guañabens, Núria

Titel

High incidence of clinical fragility fractures in postmenopausal women with rheumatoid arthritis. A case-control study

Ist Teil von

• Bone (New York, N.Y.), 2023-03, Vol.168, p.116654-116654, Article 116654

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2023

Quelle

ScienceDirect

Beschreibungen/Notizen

• To estimate the incidence of clinical fragility fractures in postmenopausal women with rheumatoid arthritis (RA) and analyze risk factors for fracture. Incidence of clinical fragility fractures in 330 postmenopausal women with RA was compared to that of a control population of 660 age-matched postmenopausal Spanish women. Clinical fractures during the previous five years were recorded. We analyzed associations with risk factors for fracture in both populations and with disease-related variables in RA patients. Median age of RA patients was 64 years; median RA duration was eight years. Sixty-nine percent were in remission or on low activity. Eighty-five percent had received glucocorticoids (GCs); 85 %, methotrexate; and 40 %, ≥1 biologic DMARD. Fifty-four patients and 47 controls had ≥1 major osteoporotic fracture (MOF). Incidence of MOFs was 3.55 per 100 patient-year in patients and 0.72 in controls (HR: 2.6). Risk factors for MOFs in RA patients were age, previous fracture, parental hip fracture, years since menopause, BMD, erosions, disease activity and disability, and cumulative dose of GCs. Previous fracture in RA patients was a strong risk for MOFs (HR: 10.37). Of every 100 postmenopausal Spanish women with RA, 3–4 have a MOF per year. This is more than double that of the general population. A previous fracture poses a high risk for a new fracture. Other classic risk factors for fracture, RA disease activity and disability, and the cumulative dose of GCs are associated with fracture development. •Fracture incidence is very high in postmenopausal women with rheumatoid arthritis.•New treatments have failed to reduce fracture risk in rheumatoid arthritis.•Patients face a high risk of new fractures if they have had a fracture previously.•Fracture prevention requires a tight control of disease activity.•Fracture prevention includes keeping glucocorticoid dose to a minimum.