Details

Autor(en) / Beteiligte

• Özen, Seval
• Kibar Gül, Ayşe Esin
• Gülhan, Belgin
• Işıksalan Özbülbül, Nilgün
• Kanık Yüksek, Saliha
• Terin, Harun
• Mustafaoğlu, Özlem
• Bayraktar, Pınar
• Ece, İbrahim
• Çetin, İbrahim İlker
• Üçkardeş, Fatih
• Bayhan, Gülsüm İclal
• Özkaya Parlakay, Aslınur

Titel

Admission and follow-up cardiac magnetic resonance imaging findings in BNT162b2 Vaccine-Related myocarditis in adolescents

Ist Teil von

• Infectious diseases (London, England), 2023-03, Vol.55 (3), p.199-206

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• There is limited data on the pattern and severity of myocardial injury in patients with COVID-19 vaccination associated myocarditis. We aimed to define the myocardial damage occurring after BNT162b2 vaccination, raise awareness about adverse reactions developing after vaccination, and determine the patterns and scope of Cardiac magnetic resonance imaging (MRI) findings. A total of 9 patients diagnosed with vaccine-associated myopericarditis were followed up. The mean age of the patient at diagnosis was 15.3 ± 1.0 (range: 14-17) years, and all patients were male. Seven patients presented with myocarditis symptoms after their second vaccine dose, one patient presented with pericarditis symptoms after his first dose, and the other patient presented with myocarditis symptoms after his booster dose. The median time at presenting to the hospital was 3 (range: 2-22) days. Seven (77.7%) patients had abnormal electrocardiography (ECG) findings, and the most prevalent finding was diffuse ST-segment elevation. Initial cardiac MRI results were abnormal in all patients, where 8 (88.8%) patients had late gadolinium enhancement, and 5 (55.5%) had myocardial edoema. Three patients showed local left ventricular wall-motion abnormalities. In their follow-up MRIs 3-6 months later, myocardial edoema was present in 2 (28.5%) patients, while late gadolinium enhancement was present in all patients (7/7, 100%, 2 patients did not have control MRI time). Hypokinetic segments were still present in one of the 3 patients. No negative cardiac events were observed in the short-term follow-up of any patient. Further follow-up evaluation and larger multicenter studies are needed to determine the clinical significance of persistent cardiac MRI abnormalities.