Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
MDM4
is an important p53-negative regulator, consequently, it is involved in cell proliferation, DNA repair, and apoptosis regulation.
MDM4
overexpression and amplification are described to lead to cancer formation, metastasis, and poor disease prognosis. Several
MDM4
SNPs are in non-coding regions, and some affect the
MDM4
regulation by disrupting the micro RNA binding site in 3'UTR (untranslated region). Here, we gathered several association studies with different
MDM4
SNPs and populations to understand the relationship between its SNPs and solid tumor risk. Many studies failed to replicate their results regarding different populations, cancer types, and risk genotypes, leading to conflicting conclusions. We suggested that distinct haplotype patterns in different populations might affect the association between
MDM4
SNPs and cancer risk. Thus, we propose to investigate some linkage SNPs in specific haplotypes to provide informative
MDM4
markers for association studies with cancer.