Chung-hua fu chʿan kʿo tsa chih, 2022-12, Vol.57 (12), p.921-931
2022
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Details
- Autor(en) / Beteiligte
- Titel
- Expression and significance of immune checkpoint B7-homolog 4 in endometrial cancer
- Ist Teil von
- Chung-hua fu chʿan kʿo tsa chih, 2022-12, Vol.57 (12), p.921-931
- Ort / Verlag
- China
- Erscheinungsjahr
- 2022
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To investigate the expression of B7 homolog 4 (B7-H4) and its clinical significance in endometrial cancer. A total of 833 patients with endometrial cancer admitted to Peking Union Medical College Hospital, Chinese Academy of Medical Sciences from 2009 to 2019, were enrolled. The expression of B7-H4, mismatch repair (MMR), p53, programmed cell death ligand 1 (PD-L1) protein, and CD T lymphocyte density in endometrial cancer tissues were detected by the EnVision two-step method of immunohistochemical staining. First-generation sequencing (Sanger method) was used to determine molecular subtyping of endometrial cancer. The test was used to compare the differences in positive expression rate of B7-H4 protein in endometrial cancer tissues with different clinicopathological features and molecular subtyping, PD-L1 protein expression, and CD T lymphocyte density. Survival analyses [including recurrence-free survival (RFS) and disease-specific survival (DSS)] were performed for 664 patients with follow-up time≥3 months
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 0529-567XDOI: 10.3760/cma.j.cn112141-20220904-00558Titel-ID: cdi_proquest_miscellaneous_2758110780
- Format
- –
- Schlagworte
- Adult, Aged, Aged, 80 and over, Biomarkers, Tumor - metabolism, Carcinoma, Endometrioid - metabolism, Carcinoma, Endometrioid - pathology, Endometrial Neoplasms - metabolism, Endometrial Neoplasms - pathology, Female, Humans, Middle Aged, Prognosis, Tumor Suppressor Protein p53 - metabolism, V-Set Domain-Containing T-Cell Activation Inhibitor 1 - metabolism