Details

Autor(en) / Beteiligte

• Mackin, R. Scott
• Jin, Chengshi
• Burns, Emily
• Kassel, Michelle
• Rhodes, Emma
• Nosheny, Rachel
• Ashford, Miriam
• Banh, Tim
• Eichenbaum, Joseph
• Knight, Kristen
• Tank, Rachana
• Camacho, Monica R.
• Fockler, Juliet
• Truran, Diana
• Neuhaus, John
• Weiner, Michael

Titel

Association of Major Depressive Disorder with remotely administered measures of cognition and subjective report of cognitive difficulties across the adult age spectrum

Ist Teil von

• Journal of affective disorders, 2023-04, Vol.326, p.198-205

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Major depressive disorder (MDD) has increasing prevalence with age. Both objective measures of cognitive dysfunction and subjective report of cognitive difficulties related to MDD are often thought to worsen with increasing age. However, few studies have directly evaluated these characteristics across the adult lifespan. Participants included 23,594 adults completing objective and subjective measures of cognition on an online research registry. Linear regression including interactions of age group with depression was used to evaluate the association of self-reported MDD with measures of cognition in three age groups: 21–40 years; 41–60 years; 61+ years. MDD (n = 2127) demonstrated poorer objective cognitive performance and greater subjective ratings of cognitive difficulties across all domains assessed compared to non-depressed individuals (ND; n = 21,467). Significant interactions of age group and MDD status with objective and subjective measures of cognition were observed for both middle age and older adults when compared to young adults but few significant differences between middle-aged and older adults were evident. This study relied on self-report of MDD diagnosis, utilized remotely administered and unsupervised measures of cognition, and the sample was not diverse. The magnitude of association between MDD and cognitive correlates appears to plateau in middle age. Our results suggest that increased rates of dementia are not due to greater cognitive consequence of MDD in older adults and that age effects, and not greater effects of depression, may lead to increased diagnosis of MDD based on subjective report of cognitive symptoms. •Adults with depression demonstrated poorer cognition and reported greater cognitive difficulties than non-depressed adults.•The association of depression with measures of cognition was greater in middle-age and older adults compared to younger adults.•Our results suggest that the strength of association between depression and cognition appears to plateau in middle-age.