Details

Autor(en) / Beteiligte

• Wang, Dan
• Tian-Fen Shao
• Wei-Hua, Ding
• Shao-Jie, Li
• Yao, Qi
• Cao, Wei
• Wang, Zheng
• Ma, Yangmin

Titel

AIE -active TPA modified Schiff base for successive sensing of Cu2+ and His via an on–off–on method and its application in bioimaging

Ist Teil von

• Dalton transactions : an international journal of inorganic chemistry, 2023-01, Vol.52 (2), p.434-443

Ort / Verlag

Cambridge: Royal Society of Chemistry

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• In this article, a novel triphenylamine-modified salicylaldehyde Schiff base 2-(((4-(diphenylamino)phenyl)imino)methyl)-4-(pyridine-4-yl)phenol (HL) was synthesized and structurally characterized. HL possessed D–π-A structure and exhibited typical AIE property in THF/H2O. It was applied to selectively recognize Cu2+ through an on–off mode in THF/H2O (1/9, v/v), and the fluorescence attenuation was attributed to a paramagnetic quenching effect of Cu2+ together with the abatement of HL aggregates. Hence, the detection limit achieved was as low as 1.32 × 10−7 M. The spectroscopic and ESI-HRMS results revealed a 1 : 2 complexation ratio of Cu2+ with HL. The mechanism for sensing Cu2+ was further confirmed by performing DFT calculations. Owing to the large affinity between Cu2+ and His, the resultant CuL2 system was further used to detect His via the off–on method based on the displacement of ligands. The detection limit for His reached 5.14 × 10−8 M. Furthermore, HL was available to prepare handy indicator papers for the on-site recognition of Cu2+ and His. Confocal fluorescent imaging demonstrated that HL could sequentially respond to intracellular Cu2+ and His.