Details

Autor(en) / Beteiligte

• Louie, Elizabeth Williams
• Berryhill, Emily H.
• Nieto, Jorge
• Wensley, Fiona
• Knych, Heather
• Finno, Carrie J.
• Morgan, Jessica M.

Titel

Changes in Heart Rate Variability with Induction of Gastric Ulcers in Adult Horses

Ist Teil von

• Journal of equine veterinary science, 2023-02, Vol.121, p.104192-104192, Article 104192

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• •Heart rate variability suggested decreased sympathetic tone in horses treated with omeprazole.•Treatment with omeprazole during ulcer induction decreases LF/HF fluctuations.•Omeprazole treatment during ulcer induction was associated with increased R-R interval. Gastric ulceration can be induced by athletic training and is a significant welfare concern. The objective of this study was to evaluate the effect of gastric ulcer induction on heart rate variability (HRV) in the horse. We hypothesized that induction of gastric ulcers would decrease HRV and increase low frequency fluctuations, consistent with increased sympathetic tone. A convenience sample of 8 horses in a larger study were enrolled. Horses were randomly assigned to receive water or 2 mg/kg omeprazole orally once daily for 28 days. Gastric ulcers were induced through intermittent feed withholding on days 21 to 28. Gastroscopy was performed and gastric ulcers were graded (0-IV) by three blinded reviewers on days 21 and 28. Continuous electrocardiograms were obtained for one hour at the start and end of ulcer induction. HRV was assessed in 1-hour recordings for time domain variables and 5 minute sections for frequency domain analysis. HRV and ulcer grade across treatments were compared by a mixed effect model, with treatment and time as fixed effects and horse as a random effect. Gastric ulcer grade increased with induction protocol (P < .0001) and decreased with omeprazole treatment (P = .0007). Omeprazole treatment increased R-R intervals (P = .01) and decreased ratio of low frequency/high frequency signal (P = .008) as compared to horses receiving water. This was attributable to decreasing low frequency fluctuations (P = .05). While limited by the small sample size (four horses/treatment), this study suggests that omeprazole treatment decreases heart rate, and LF/HF ratio during ulcer induction, consistent with a decrease in sympathetic tone.