Details

Autor(en) / Beteiligte

• Sotiropoulos, James X.
• Schmölzer, Georg M.
• Oei, Ju Lee
• Libesman, Sol
• Hunter, Kylie E.
• Williams, Jonathan G.
• Webster, Angela C.
• Tarnow‐Mordi, William O.
• Vento, Maximo
• Asztalos, Elizabeth
• Shah, Prakesh S.
• Katheria, Anup
• Seidler, Anna Lene

Titel

PROspective Meta‐analysis Of Trials of Initial Oxygen in preterm Newborns (PROMOTION): Protocol for a systematic review and prospective meta‐analysis with individual participant data on initial oxygen concentration for resuscitation of preterm infants

Ist Teil von

• Acta Paediatrica, 2023-03, Vol.112 (3), p.372-382

Ort / Verlag

Norway: Wiley Subscription Services, Inc

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Background Clinicians favour low oxygen concentrations when resuscitating preterm infants immediately after birth despite inconclusive evidence to support this practice. Prospective meta‐analysis (PMA) is a novel approach where studies are identified as eligible for inclusion in the meta‐analysis before their results are known. Aims To explore whether high (60%) or low (30%) oxygen is associated with greater efficacy and safety for the initial resuscitation (immediately after birth) of preterm infants born at <29 weeks' gestation. Methods We will conduct a prospective meta‐analysis (PMA) with individual participant data (IPD). We will perform a systematic search to identify ongoing RCTs including infants <29 weeks' gestation randomised to high (60%) or low (30%) oxygen for initial resuscitation after birth. IPD will be sought for all infants randomised for the purpose of meta‐analysis. We will employ a one‐stage random‐effects approach to IPD meta‐analysis. Potential heterogeneity and the differential effect of high or low oxygen will be explored through subgroup and interaction analyses. The primary outcome of this study is all‐cause mortality prior to hospital discharge. There will be a follow‐up analysis of neurodevelopmental outcomes once available. Results/Conclusion The results of neonatal outcomes at hospital discharge are expected by 2025, and neurodevelopmental outcomes by 2027.