Details

Autor(en) / Beteiligte

• YU, Wenqi
• REN, Chaochao
• ZHANG, Ning
• CAO, Li
• WEIR, Michael D.
• YANG, Kai
• XU, Hockin H. K.
• BAI, Yuxing

Titel

Dual function of anti-biofilm and modulating biofilm equilibrium of orthodontic cement containing quaternary ammonium salt

Ist Teil von

• Dental Materials Journal, 2023/03/25, Vol.42(2), pp.149-157

Ort / Verlag

Japan: The Japanese Society for Dental Materials and Devices

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• The objectives of this study were to incorporate dimethylaminohexadecyl methacrylate (DMAHDM) into resin-modified glass ionomer cement (RMGI) to develop a novel orthodontic cement which endowed RMGI with strong antibacterial ability and investigated its modulation biofilm equilibrium from cariogenic state to non-cariogenic state for the first time. Cariogenic Streptococcus mutans (S. mutans), and non-cariogenic Streptococcus sanguinis (S. sanguinis) and Streptococcus gordonii (S. gordonii) were selected to form a tri-species biofilm model. RMGI incorporated with different mass fraction of DMAHDM was examined: biofilm colony-forming units, metabolic activity, live/dead staining, lactic acid and exopolysaccharides productions. TaqMan real-time polymerase chain reaction was used to determine changes of biofilm species compositions. The results showed RMGI containing 3% DMAHDM achieved strong antibacterial ability and suppressed the cariogenic species in biofilm, modulating biofilm equilibrium from cariogenic state to non-cariogenic state tendency. The novel bioactive cement containing DMAHDM is promising in fixed orthodontic treatments and protecting tooth enamel.