Details

Autor(en) / Beteiligte

• Lauridsen, Karin Holst
• Olsen, Kristine Boisen
• Lund, Eva Løbner
• Jensen, Tomas O
• Pedersen, Thomas Ingemann
• Harboe, Zitta Barrella
• Antsupova, Valeria
• Rasmussen, Lasse Dam
• Röser, Dennis
• Banner, Jytte
• Franck, Kristina Træholt
• Vorobieva Solholm Jensen, Veronika

Titel

Neurological Complications in COVID-19 Patients: Can Analysis of Specific Antibodies and Viral RNA in Paired Cerebrospinal Fluid and Serum be Used for Accurate Diagnosis of SARS-CoV-2 Neuroinflammatory Disease? A Case Series

Ist Teil von

• Clinical pathology (Thousand Oaks, Ventura County, Calif.), 2022, Vol.15, p.2632010X221139096-2632010X221139096

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• BackgroundNeurological complications during and after SARS-CoV-2 infection have been frequently described. The detection of either SARS-CoV-2 RNA or specific antibodies against SARS-CoV-2 in cerebrospinal fluid in the context of concomitant neurological manifestations indicates neuroinfection. Methods and ResultsThis is a retrospective descriptive analysis of cerebrospinal fluids and serum samples from 2 hospitalized patients and autopsy findings from 2 patients who died at home. Samples were analysed by 3 independent enzyme-linked immunosorbent assays. Specific antibodies against SARS-CoV-2 were detected in cerebrospinal fluids and paired serum in all 4 cases. Levels of antibodies in cerebrospinal fluids were highest in samples from a deceased man with critical progression of COVID-19 and detectable SARS-CoV-2 viral RNA in cerebrospinal fluid, serum, 4 brain biopsies and 15 additional tissue samples, though immunohistochemical staining for SARS-CoV-2 in brain tissue did not detect the virus. ConclusionDetection of SARS-CoV-2 antibodies in paired serum and cerebrospinal fluid may support the presence of SARS-CoV-2 neuroinflammatory disease in patients with COVID-19 and neurological manifestations.