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Platelet‐Derived Growth Factor B Is a Key Element in the Pathological Bone Formation of Ankylosing Spondylitis
Journal of bone and mineral research, 2023-02, Vol.38 (2), p.300-312
Jo, Sungsin
Lee, Seung Hoon
Park, Jinsung
Nam, Bora
Kim, Hyunsung
Youn, Jeehee
Lee, Seunghun
Kim, Tae‐Jong
Sung, Il‐Hoon
Choi, Sung Hoon
Park, Ye‐Soo
Inman, Robert D
Kim, Tae‐Hwan
2023
Volltextzugriff (PDF)
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Autor(en) / Beteiligte
Jo, Sungsin
Lee, Seung Hoon
Park, Jinsung
Nam, Bora
Kim, Hyunsung
Youn, Jeehee
Lee, Seunghun
Kim, Tae‐Jong
Sung, Il‐Hoon
Choi, Sung Hoon
Park, Ye‐Soo
Inman, Robert D
Kim, Tae‐Hwan
Titel
Platelet‐Derived Growth Factor B Is a Key Element in the Pathological Bone Formation of Ankylosing Spondylitis
Ist Teil von
Journal of bone and mineral research, 2023-02, Vol.38 (2), p.300-312
Ort / Verlag
Hoboken, USA: John Wiley & Sons, Inc
Erscheinungsjahr
2023
Quelle
Wiley Blackwell Single Titles
Beschreibungen/Notizen
ABSTRACT Enthesophyte formation plays a crucial role in the development of spinal ankylosis in ankylosing spondylitis (AS). We aimed to investigate the role of platelet‐derived growth factor B (PDGFB) in enthesophyte formation of AS using in vitro and in vivo models and to determine the association between PDGFB and spinal progression in AS. Serum PDGFB levels were measured in AS patients and healthy controls (HC). Human entheseal tissues attached to facet joints or spinous processes were harvested at the time of surgery and investigated for bone‐forming activity. The impact of a pharmacological agonist and antagonist of platelet‐derived growth factor B receptor (PDGFRB) were investigated respectively in curdlan‐treated SKG mice. PDGFB levels were elevated in AS sera and correlated with radiographic progression of AS in the spine. Mature osteoclasts secreting PDGFB proteins were increased in the AS group compared with HC and were observed in bony ankylosis tissues of AS. Expression of PDGFRB was significantly elevated in the spinous enthesis and facet joints of AS compared with controls. Moreover, recombinant PDGFB treatment accelerated bone mineralization of enthesis cells, which was pronounced in AS, whereas PDGFRB inhibition efficiently reduced the PDGFB‐induced bone mineralization. Also, PDGFRB inhibition attenuated the severity of arthritis and enthesophyte formation at the joints of curdlan‐treated SKG mice. This study suggests that regulating PDGFB/PDGFRB signaling could be a novel therapeutic strategy to block key pathophysiological processes of AS. © 2022 American Society for Bone and Mineral Research (ASBMR).
Sprache
Englisch
Identifikatoren
ISSN: 0884-0431
eISSN: 1523-4681
DOI: 10.1002/jbmr.4751
Titel-ID: cdi_proquest_miscellaneous_2739740143
Format
–
Schlagworte
Animals
,
ANKYLOSING SPONDYLITIS
,
Ankylosis
,
Arthritis
,
Bone growth
,
BONE MINERALIZATION
,
Bone surgery
,
ENTHESIS
,
ENTHESOPHYTE FORMATION
,
Growth factors
,
Humans
,
Joint diseases
,
Mice
,
Mineralization
,
Ossification, Heterotopic - genetics
,
Ossification, Heterotopic - metabolism
,
Osteoclasts
,
Osteogenesis
,
PDGFB/PDGFRB SIGNALING
,
Platelets
,
Proto-Oncogene Proteins c-sis - genetics
,
Proto-Oncogene Proteins c-sis - metabolism
,
Receptor, Platelet-Derived Growth Factor beta - antagonists & inhibitors
,
Receptor, Platelet-Derived Growth Factor beta - genetics
,
Receptor, Platelet-Derived Growth Factor beta - metabolism
,
Spinal Osteophytosis - genetics
,
Spinal Osteophytosis - metabolism
,
Spine - diagnostic imaging
,
Spine - metabolism
,
Spine - pathology
,
Spondylitis, Ankylosing - genetics
,
Spondylitis, Ankylosing - metabolism
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