Details

Autor(en) / Beteiligte

• Groen in ‘t Woud, Sander
• Roeleveld, Nel
• Westland, Rik
• Renkema, Kirsten Y.
• Steffens, Martijn G.
• Gracchi, Valentina
• Lilien, Marc R.
• van Wijk, Joanna A.E.
• Feitz, Wout F.J.
• Schreuder, Michiel F.
• van der Zanden, Loes F.M.
• Beeren, M.C.G.
• Blokland-Loggers, H.E.
• Breukels, M.
• van den Broek, L.M.
• del Canho, R.
• Creemers, D.
• van Dael, C.M.L.
• van der Deure, H.
• Dings-Lammertink, A.
• Dorrepaal, C.
• Dorresteijn, E.
• Feitz, W.F.J.
• Gracchi, V.
• Groen in ‘t Woud, S.
• Harnisch, E.
• Jacobs, M.J.
• Jira, P.E.
• Keijzer-Veen, M.G.
• Kloosterman, F.J.
• Knots, E.
• Konijnenberg, A.Y.
• Koppejan-Stapel, M.
• van der Kuur, E.C.
• van Ledden-Klok, M.J.
• Leunissen, R.W.J.
• Lilien, M.R.
• Jansen, C. Meine
• de Moor, R.
• Nijhuis, I.J.M.
• Pierik, L.J.W.M.
• Pijning, A.
• de Pont, S.M.H.B.
• Renkema, K.Y.
• Rijlaarsdam, R.
• Roeleveld, N.
• van Rooij, R.W.G.
• Schreuder, M.F.
• Semmekrot, B.
• Steffens, M.G.
• Tanja, A.L.
• Westland, R.
• van Wijk, J.A.E.
• Wijnands - van den Berg, E.
• van der Zanden, L.F.M.
• Zegers, B.

Titel

Uncovering risk factors for kidney injury in children with a solitary functioning kidney

Ist Teil von

• Kidney international, 2023-01, Vol.103 (1), p.156-165

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Children with a solitary functioning kidney (SFK) have an increased risk of kidney injury. The exact risk of and risk factors for kidney injury remain unknown, which impedes personalized care. Here, we recruited a nationwide multicenter cohort of 944 patients with SFK to get more insight into this by consenting patients born in 1993-2020 and diagnosed with congenital or acquired SFK before adulthood. The median follow-up was 12.8 years and four indications of kidney injury were studied: urine protein-creatinine ratios, blood pressure, estimated glomerular filtration rate and use of anti-hypertensive/proteinuric medication. For each indicator except medication use, separate cut-off values for any injury and severe injury were used. Survival analyses indicated that at 18 years of age, any or severe kidney injury were present in 75% and 39% of patients with congenital SFK, respectively. Risk factors for kidney injury included kidney agenesis as cause of the SFK, anomalies in the SFK, and high body mass index at last follow-up. Kidney agenesis and being overweight were specifically associated with proteinuria and high blood pressure, whereas anomalies in the SFK were associated with reduced estimated glomerular filtration rates. The high prevalence of kidney injury in patients with SFK emphasizes the need for long-term follow-up, in which lifestyle is an important topic to address. More research into the etiological role of risk factors will help to translate our findings into individualized care strategies. Thus, our study shows that a significant proportion of children with SFK will develop kidney injury over time. [Display omitted]