Details

Autor(en) / Beteiligte

• Sunderland, Kelly M.
• Beaton, Derek
• Arnott, Stephen R.
• Kleinstiver, Peter
• Kwan, Donna
• Lawrence‐Dewar, Jane M.
• Ramirez, Joel
• Tan, Brian
• Bartha, Robert
• Black, Sandra E.
• Borrie, Michael
• Brien, Donald
• Casaubon, Leanne K.
• Coe, Brian C.
• Cornish, Benjamin
• Dilliott, Allison A.
• Dowlatshahi, Dar
• Finger, Elizabeth
• Fischer, Corinne
• Frank, Andrew
• Fraser, Julia
• Freedman, Morris
• Greenberg, Barry
• Grimes, David A.
• Hassan, Ayman
• Hatch, Wendy
• Hegele, Robert A.
• Hudson, Christopher
• Jog, Mandar
• Kumar, Sanjeev
• Lang, Anthony
• Levine, Brian
• Lou, Wendy
• Mandzia, Jennifer
• Marras, Connie
• McIlroy, William
• Montero‐Odasso, Manuel
• Munoz, David G.
• Munoz, Douglas P.
• Orange, Joseph B.
• Park, David S.
• Pasternak, Stephen H.
• Pieruccini‐Faria, Frederico
• Rajji, Tarek K.
• Roberts, Angela C.
• Robinson, John F.
• Rogaeva, Ekaterina
• Sahlas, Demetrios J.
• Saposnik, Gustavo
• Scott, Christopher J.M.
• Seitz, Dallas
• Shoesmith, Christen
• Steeves, Thomas D.L.
• Strong, Michael J.
• Strother, Stephen C.
• Swartz, Richard H.
• Symons, Sean
• Tang‐Wai, David F.
• Tartaglia, Maria Carmela
• Troyer, Angela K.
• Turnbull, John
• Zinman, Lorne
• McLaughlin, Paula M.
• Masellis, Mario
• Binns, Malcolm A.
• Abrahao, Agessandro
• Adamo, Sabrina
• Berezuk, Courtney
• Black, Alanna
• Breen, David P.
• Bulman, Dennis
• Chen, Ying
• El‐Defrawy, Sherif
• Farhan, Sali
• Ghani, Mahdi
• Gonder, John
• Haddad, Seyyed M. H.
• Holmes, Melissa
• Huang, Jeff
• Leontieva, Elena
• Mandelcorn, Efrem
• Margolin, Edward
• Nanayakkara, Nuwan
• Ozzoude, Miracle
• Peltsch, Alicia J.
• Pollock, Bruce
• Raamana, Pradeep
• Rashkovan, Natalie
• Yanina
• Southwell, Alisia
• Sujanthan, Sujeevini
• Tayyari, Faryan
• Van Ooteghem, Karen
• Woulfe, John
• Zamyadi, Mojdeh
• Zou, Guangyong

Titel

Characteristics of the Ontario Neurodegenerative Disease Research Initiative cohort

Ist Teil von

• Alzheimer's & dementia, 2023-01, Vol.19 (1), p.226-243

Ort / Verlag

United States

Erscheinungsjahr

2023

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Introduction Understanding synergies between neurodegenerative and cerebrovascular pathologies that modify dementia presentation represents an important knowledge gap. Methods This multi‐site, longitudinal, observational cohort study recruited participants across prevalent neurodegenerative diseases and cerebrovascular disease and assessed participants comprehensively across modalities. We describe univariate and multivariate baseline features of the cohort and summarize recruitment, data collection, and curation processes. Results We enrolled 520 participants across five neurodegenerative and cerebrovascular diseases. Median age was 69 years, median Montreal Cognitive Assessment score was 25, median independence in activities of daily living was 100% for basic and 93% for instrumental activities. Spousal study partners predominated; participants were often male, White, and more educated. Milder disease stages predominated, yet cohorts reflect clinical presentation. Discussion Data will be shared with the global scientific community. Within‐disease and disease‐agnostic approaches are expected to identify markers of severity, progression, and therapy targets. Sampling characteristics also provide guidance for future study design.