Journal of organic chemistry, 2022-11, Vol.87 (22), p.15435-15447
2022
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Details
- Autor(en) / Beteiligte
- Titel
- Synthesis of Pyrrolo[2,1‑a]isoquinolines through Cu-Catalyzed Condensation/Addition/Oxidation/Cyclization Cascade
- Ist Teil von
- Journal of organic chemistry, 2022-11, Vol.87 (22), p.15435-15447
- Ort / Verlag
- United States: American Chemical Society
- Erscheinungsjahr
- 2022
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We have developed a copper-catalyzed synthesis of pyrrolo[2,1-a]isoquinolines with terminal alkynes, aldehydes, and tetrahydroisoquinolines. A variety of pyrrolo[2,1-a]isoquinolines have been prepared in 17–69% yield via a condensation/Mannich-type addition/oxidation/cyclization cascade sequence. Modifications through simple chemical transformations provided highly functionalized molecules containing a privileged framework.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-3263eISSN: 1520-6904DOI: 10.1021/acs.joc.2c01978Titel-ID: cdi_proquest_miscellaneous_2730643704
- Format
- –
- Schlagworte
- Alkynes - chemistry, Catalysis, Copper - chemistry, Cyclization, Isoquinolines - chemistry, Molecular Structure