Details

Autor(en) / Beteiligte

• Bi, De-Wen
• Xiong, Feng
• Cheng, Bin
• Zhou, Ya-Ling
• Zeb, Muhammad Aurang
• Tang, Peng
• Pang, Wen-Hui
• Zhang, Rui-Han
• Li, Xiao-Li
• Zhang, Xing-Jie
• Xiao, Wei-Lie

Titel

Callintegers A and B, Unusual Tricyclo[4.4.0.09,10]tetradecane Clerodane Diterpenoids from Callicarpa integerrima with Inhibitory Effects on NLRP3 Inflammasome Activation

Ist Teil von

• Journal of natural products (Washington, D.C.), 2022-11, Vol.85 (11), p.2675-2681

Ort / Verlag

United States: American Chemical Society and American Society of Pharmacognosy

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Callintegers A (1) and B (2), unprecedented clerodane norditerpenoids based on a novel carbon skeleton, were isolated from Callicarpa integerrima. Compounds 1 and 2 possess a novel 6/6/6-fused tricyclic ring system. Their structures and absolute configurations were determined by quantum chemical calculations, spectroscopic analysis, and single-crystal X-ray diffraction methods. Biological evaluation showed that compound 2 inhibited IL-1β secretion in a dose-dependent manner with an IC50 value of 5.5 ± 3.2 μM. Caspase-1 maturation and IL-1β secretion were also reduced, indicating that compound 2 impaired NLRP3 inflammasome activation.