Details

Autor(en) / Beteiligte

• Yan, Jie
• Nie, Dong-hang
• Bai, Cheng-si
• Rehman, Abdul
• Yang, An
• Mou, Xiao-Li
• Zhang, Yu-qing
• Xu, Ying-qi
• Xiang, Qing-qing
• Ren, Yu-ting
• Xu, Jia-le
• Wang, Mei-rong
• Feng, Yong
• Chen, Xiao-ping
• Xiong, Yong
• Hu, Hai-tao
• Xiong, Hai-rong
• Hou, Wei

Titel

Fentanyl enhances HIV infection in vitro

Ist Teil von

• Virology (New York, N.Y.), 2022-12, Vol.577, p.43-50

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Acquired immunodeficiency syndrome (AIDS) caused by Human immunodeficiency virus type 1 (HIV-1) has a high tendency among illicit drug abusers. Recently, it is reported that abuse of fentanyl, a potent synthetic μ receptor–stimulating opioid, is an independent risk factor for HIV-1 infection. However, the mechanism of action in augmenting HIV-1 infection still remains elusive. In this study, we found that fentanyl enhanced infection of HIV-1 in MT2 cells, primary macrophages and Jurkat C11 cells. Fentanyl up-regulated CXCR4 and CCR5 receptor expression, which facilitated the entry of virion into host cells. In addition, it down-regulated interferon-β (IFN-β) and interferon-stimulated genes (APOBEC3F, APOBEC3G and MxB) expression in MT2 cells. Our findings identify an essential role of fentanyl in the positive regulation of HIV-1 infection via the upregulation of co-receptors (CXCR4/CCR5) and downregulation of IFN-β and ISGs, and it may have an important role in HIV-1 immunopathogenesis. •Fentanyl enhances infection of HIV-1 in MT2, primary macrophages, Jurkat C11 cells.•Fentanyl promotes the expression of CXCR4 and CCR5 receptors.•Fentanyl inhibits interferon-β and interferon-stimulated genes expression.