Details

Autor(en) / Beteiligte

• Laserna-Mendieta, Emilio José
• Navarro, Pilar
• Casabona-Francés, Sergio
• Savarino, Edoardo V
• Pérez-Martínez, Isabel
• Guagnozzi, Danila
• Barrio, Jesús
• Perello, Antonia
• Guardiola-Arévalo, Antonio
• Betoré-Glaria, María Elena
• Blas-Jhon, Leonardo
• Racca, Francesca
• Krarup, Anne Lund
• Gutiérrez-Junquera, Carolina
• Fernández-Fernández, Sonia
• la Riva, Susana De
• Naves, Juan E
• Carrión, Silvia
• García-Morales, Natalia
• Roales, Valentín
• Rodríguez-Oballe, Juan Armando
• Dainese, Raffaella
• Rodríguez-Sánchez, Alba
• Masiques-Mas, María Lluisa
• Feo-Ortega, Sara
• Ghisa, Matteo
• Maniero, Daria
• Suarez, Adolfo
• Llerena-Castro, Ronald
• Gil-Simón, Paula
• de la Peña-Negro, Luisa
• Granja-Navacerrada, Alicia
• Alcedo, Javier
• Hurtado de Mendoza-Guena, Lonore
• Pellegatta, Gaia
• Pérez-Fernández, María Teresa
• Santander, Cecilio
• Tamarit-Sebastián, Sonsoles
• Arias, Ángel
• Lucendo, Alfredo J.

Titel

Differences between childhood- and adulthood-onset eosinophilic esophagitis: An analysis from the EoE connect registry

Ist Teil von

• Digestive and liver disease, 2023-03, Vol.55 (3), p.350-359

Ort / Verlag

Netherlands: Elsevier Ltd

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Direct comparisons of childhood- and adulthood-onset eosinophilic esophagitis (EoE) are scarce. To compare disease characteristics, endoscopic and histological features, allergic concomitances and therapeutic choices across ages. Cross-sectional analysis of the EoE CONNECT registry. The adulthood-onset cohort (those diagnosed at ≥18y) comprised 1044 patients and the childhood‐onset cohort (patients diagnosed at <18 y), 254. Vomiting, nausea, chest and abdominal pain, weight loss, slow eating and food aversion were significantly more frequent in children; dysphagia, food bolus impaction and heartburn predominated in adults. A family history of EoE was present in 16% of pediatric and 8.2% of adult patients (p<0.001). Concomitant atopic diseases did not vary across ages. Median±IQR diagnostic delay (years) from symptom onset was higher in adults (2.7 ± 6.1) than in children (1 ± 2.1; p<0.001). Esophageal strictures and rings predominated in adults (p<0.001), who underwent esophageal dilation more commonly (p = 0.011). Inflammatory EoE phenotypes were more common in children (p = 0.001), who also presented higher eosinophil counts in biopsies (p = 0.015) and EREFS scores (p = 0.017). Despite PPI predominating as initial therapy in all cohorts, dietary therapy and swallowed topical corticosteroids were more frequently prescribed in children (p<0.001). Childhood‐onset EoE has differential characteristics compared with adulthood-onset, but similar response to treatment.