Details

Autor(en) / Beteiligte

• Loubet, Dorian
• Sarton, Benjamine
• Lelièvre, Lucie
• Grouteau, Gaspard
• Iriart, Xavier
• Chauvin, Pamela
• Fillaux, Judith
• Valentin, Alexis
• Berry, Antoine
• Silva, Stein
• Bonneville, Fabrice
• Cassaing, Sophie
• Guemas, Emilie

Titel

Fatal mucormycosis and aspergillosis coinfection associated with haemophagocytic lymphohistiocytosis: A case report and literature review

Ist Teil von

• Journal de mycologie médicale, 2023-03, Vol.33 (1), p.101325-101325, Article 101325

Ort / Verlag

France: Elsevier Masson SAS

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Invasive mould infections are life-threatening and mainly occur in immunocompromised patients. Whereas aspergillosis is described during haemophagocytic lymphohistiocytosis (HLH), only a few cases of concomitant mucormycosis with HLH have been reported. Here, we present an uncommon coinfection of mucormycosis and aspergillosis associated with HLH probably due to a varicella zoster virus (VZV) viraemia which was unresponsive to triple antifungal therapy (liposomal amphotericin B combined with isavuconazole and caspofungin). A review of the cases of mucormycosis with HLH showed that this uncommon association was always lethal and underscored the relevance of screening for mould infections in patients with HLH.