Details

Autor(en) / Beteiligte

• Bradshaw, Lucy E.
• Wyatt, Laura A.
• Brown, Sara J.
• Haines, Rachel H.
• Montgomery, Alan A.
• Perkin, Michael R.
• Lawton, Sandra
• Sach, Tracey H.
• Chalmers, Joanne R.
• Ridd, Matthew J.
• Flohr, Carsten
• Brooks, Joanne
• Swinden, Richard
• Mitchell, Eleanor J.
• Tarr, Stella
• Jay, Nicola
• Thomas, Kim S.
• Allen, Hilary
• Cork, Michael J.
• Kelleher, Maeve M.
• Simpson, Eric L.
• Lartey, Stella T.
• Davies‐Jones, Susan
• Boyle, Robert J.
• Williams, Hywel C.

Titel

Emollients for prevention of atopic dermatitis: 5‐year findings from the BEEP randomized trial

Ist Teil von

• Allergy (Copenhagen), 2023-04, Vol.78 (4), p.995-1006

Ort / Verlag

Denmark: Blackwell Publishing Ltd

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Background The effectiveness of emollients for preventing atopic dermatitis/eczema is controversial. The Barrier Enhancement for Eczema Prevention trial evaluated the effects of daily emollients during the first year of life on atopic dermatitis and atopic conditions to age 5 years. Methods 1394 term infants with a family history of atopic disease were randomized (1:1) to daily emollient plus standard skin‐care advice (693 emollient group) or standard skin‐care advice alone (701 controls). Long‐term follow‐up at ages 3, 4 and 5 years was via parental questionnaires. Main outcomes were parental report of a clinical diagnosis of atopic dermatitis and food allergy. Results Parents reported more frequent moisturizer application in the emollient group through to 5 years. A clinical diagnosis of atopic dermatitis between 12 and 60 months was reported for 188/608 (31%) in the emollient group and 178/631 (28%) in the control group (adjusted relative risk 1.10, 95% confidence interval 0.93 to 1.30). Although more parents in the emollient group reported food reactions in the previous year at 3 and 4 years, cumulative incidence of doctor‐diagnosed food allergy by 5 years was similar between groups (92/609 [15%] emollients and 87/632 [14%] controls, adjusted relative risk 1.11, 95% confidence interval 0.84 to 1.45). Findings were similar for cumulative incidence of asthma and hay fever. Conclusions Daily emollient application during the first year of life does not prevent atopic dermatitis, food allergy, asthma or hay fever. Graphical 1394 newborns at high risk of atopic dermatitis randomized to either daily emollients (Doublebase Gel [Dermal Laboratories] or Diprobase Cream [Bayer]) for 12 months or standard skin care advice. Regular emollients did not prevent atopic dermatitis, food allergy, asthma or allergic rhinitis during the first 5 years of life. Severity of atopic dermatitis similar in the two groups at 5 years.Abbreviation: AD, atopic dermatitis